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CASE STUDY

Smart Column Coupling: Overcoming a Three-Way Separation

Challenge

The goal was to separate a starting material and two product isomers, but no single HPLC column could resolve all three.

Approach

  • Kinetex resolved the isomers but not the SM
  • X-Select resolved the SM but not the isomers
  • Solution: Serially connected both columns

 

Outcome

  • Full resolution achieved in one injection
  • Reduced time, complexity, and purification steps
  • Pure collection of the two desired isomers
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< Analytical Chemistry and Separation Sciences