Challenging Chemistry?
An overseas CRO had been working for 8 months to enable scaling up from 10mg synthesis to 1g synthesis but a troublesome step did not allow scale up further than 100mg. NuChem was mandated to investigate the issue and within 2 days, NuChem identified the problem as an undesired reaction pathway leading to a side product. We redesigned the route which enabled a 1 kg synthesis to proceed a few months later.
Synthetic Chemistry Mandates
Custom synthesis
At NuChem Sciences our team of chemists possesses extensive experience in synthetic chemistry. We provide custom synthesis services to both academia and industry. Whether your target is a single compound, a set of compounds or a compound library, we are dedicated to executing each project to the high standards expected by our clients. Our knowledgeable and resourceful scientists are capable of tackling and solving the most challenging synthetic problems.
- FFS or FTE
- Assess project status and identify chemistry issues
- Resolve chemistry issues
- Enable core synthesis
- Enable analog synthesis
- Project management
Medicinal Chemistry Mandates
Medicinal Chemistry is a core expertise of NuChem Sciences. Our primary asset is our knowledgeable, experienced, and creative scientists who draw upon years of experience in early stage drug discovery acquired across a wide range of therapeutic areas and biological targets. Through hit identification and productive analogue design and synthesis, we can help you identify and optimize pre-clinical candidates in the area of small molecule drug discovery. NuChem delivers excellence through thoughtful interpretation and rational integration of tractable SAR and PK/ADME results into the design-make-test-analyze cycle. Our medicinal chemistry team is committed to rapidly advancing your research programs by providing fast, flexible and innovative solutions.
- Same as synthetic chemistry plus
- Design and synthesis of analogs or focused libraries
- Work with biology to generate, compile and analyze data
- Work with computational to establish SAR
- Project management including external service providers
Route Scouting and Process Development
Our process development group is composed of highly skilled and creative organic chemists having significant experience in synthetic process development of drug candidates, intermediate compounds, and building blocks. The group uses state of the art chemistry methodologies and creative design of synthetic routes to develop processes suitable for the large-scale manufacturing of drug candidates, and executes the preparation of complex challenging molecules in house using these processes. We work as an extension of our customer’s internal R&D teams providing high quality FTE services at competitive rates and meeting project timelines.
Expert Consulting
- Asset Evaluation
- Prior Art Analysis
- Determination of freedom to operate (FTO) followed by the approval of customer’s legal counsel
- Molecular Modeling of Ligand-Protein Interactions
- Proprietary Compound Design with Elaborate Synthesis Proposal
- MedChem Strategy
- Generation of a Full Drug Discovery Work Plan Including Scale-up and Synthetic Process Development of Potential Drug Candidate
- Providing Detailed Budget with Deliverables and Timelines
- Project management including external service providers
Computational Chemistry
Our computational chemistry scientists work very closely with our medicinal chemistry team for a uniquely efficient evaluation and alignment of project fundamentals and align thinking.
- Optimize existing structural model
- Validate docking protocol
- Support medicinal chemistry to establish SAR
- Use of specialized tools to predict ADME-TOX properties
Analytical Chemistry
This specialized team is in place to develop and run analytical method for chemical development, purity, impurity profiles, medchem and ADME support including bioanalytical services.
- Physicochemical Properties
- Purity determination (chemical and chiral)
- Analytical method development
- Purity and impurity profile determinations
- IPC’s
- Bioanalytical
Route Scouting & Process Development
Our process development group is composed of highly skilled and creative organic chemistry scientists having significant experience in synthetic chemistry and process development of drug candidates, intermediate compounds, and building blocks. The group uses state of the art chemistry methodologies and creative design of synthetic routes to develop processes suitable for the larger-scale manufacturing of drug candidates and executes the preparation of complex challenging molecules in house using these processes.
- Route Scouting
- Process Development
- Scale up
Purification Group
Your core team of FTEs can handle purification on their own but to optimize their time, you can have them use the optional internal purification services.
- Support synthetic and medicinal chemistry separation needs
Transform Ideas Through Science
A drug discovery and chemical development contract research organization.
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NuChem Sciences Inc.
2350 Rue Cohen Suite 201
Saint-Laurent, Quebec
Canada H4R 2N6
514 416 5659