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SCIENTIST, COMPUTATIONAL CHEMISTRY

NuChem Sciences, a synthetic chemistry and biology contract research organization, is expanding and looking for candidates to fill a Scientist position in our Computational Chemistry department. The candidates specialized in computational and medicinal chemistry will be working from our new facilities in Saint-Laurent, Montreal. NuChem provides integrated services to early drug discovery projects for our clients spanning from Medicinal Chemistry, Process Chemistry, ADME/PK, Biochemistry, Cell Biology and In Vivo Pharmacology, in the area of small molecule drug discovery.

We are a dynamic team consisting of experienced scientists and fresh graduates where everyone contributes their ideas and talents towards a variety of diverse projects. We believe in a work environment that should be fun, safe and productive with fully equipped, state-of-the art laboratories and facilities offering flexible work hours. We are focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work. 

We are seeking a highly motivated entry-level computational scientist to join our established team working on a variety of programs with a particular focus on hit-finding, hit-to-lead development, and lead optimization. The highly qualified individual is expected to have experience in computational chemistry applied to drug discovery, medicinal chemistry and basic knowledge of synthetic organic chemistry. Key aspects of the role are being able to work within a team structure, apply computational tools to rationalize experimental results and propose new chemical designs. 

RESPONSIBILITIES:

  • Apply computational methods in structure- and ligand-based approaches for the design of small molecules inhibitors or modulators of target proteins with attention to desired drug-like and physicochemical properties;

  • Help synthetic organic chemists in the prioritization of proposed analogues;

  • Facilitate the creative iteration of ideas proposed by the candidate and the chemistry team while ensuring a positive and constructive feedback loop;

  • Communicate results to an audience of mixed expertise in a clear and concise manner;

  • Actively participate in scientific discussions with the team and the client;

  • Interaction with medicinal chemists, biologists, and DMPK colleagues to align strategies and approaches towards the goal of the program;

  • Keep abreast of relevant literature and maintain a high level of expertise in own field;

  • Work under the supervision of the Director or the Project Manager in order to achieve the objectives of the project in line with those of the client.

REQUIREMENTS:

  • PhD in organic and/or computational chemistry or MSc with several years of experience.

  • Good knowledge of medicinal chemistry and drug discovery principles is required.

  • A working knowledge of organic chemistry is required.

  • Proven experience with molecular modeling software such as MOE (preferred) and Schrödinger is required.

  • Proven experience with performing docking studies is required, along with a critical understanding of the applicability and limitation of computational tools and results.

  • Experience with hit discovery and optimization is an asset.

  • Bilingual an asset.

  • Excellent written, organizational, and documentation skills.

  • Proactive with strong interpersonal skills; able to thrive in a team-based environment.

  • Demonstrated ability to troubleshoot and creatively problem solve.

  • Proficiency in Microsoft Office (Word, Excel, and PowerPoint).

  • Ability to communicate progress effectively with colleagues, managers, and clients both in written and verbal form.

  • Applicants must be eligible to work in Canada (Canadian citizen, permanent resident or work permit).

COMPENSATION AND BENEFITS: 

Salary: 

  • Competitive and based on experience. 

Additional pay: 

  • Annual bonus incentive plan. 

Advantages: 

  • Full time permanent position; 
  • Health and dental care insurance plan; 
  • Short- and long-term disability insurance; 
  • Life insurance;
  • RRSP employer’s matching program;
  • Casual dress code;
  • Flexible schedule;
  • On-site free parking;
  • Continuing education;
  • Career development.

Schedule: 

  • Monday to Friday. 

Apply today to work with state-of-the-art research facility and become part of the NuChem Sciences Drug Discovery Team! 

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