Associate Director, DMPK


NuChem Sciences, a Sygnature Discovery business is a world-leading integrated drug discovery Contract Research Organisation based in the UK and Canada with its headquarters in Nottingham and additional facilities in Alderley Park, Macclesfield, Glasgow, Montreal and Quebec City.  Its staff of over 1,000, which includes 900 scientists, partners with global pharma, biotech and NFP organisations.

Since 2004, Sygnature Discovery has delivered over 40 novel pre-clinical and 22 clinical compounds, with its scientists named on over 170 patents.  Therapeutic areas of expertise include oncology, inflammation and immunology, neuroscience, metabolic diseases, infectious diseases, fibrotic diseases and more.

About the role

At Sygnature Discovery, our DMPK scientists play an essential role in collaborating within an integrated drug discovery projects covering a broad range of molecular targets and therapeutic indications. We currently have an open position for a motivated Associate Director to support our DMPK team.  Our DMPK continues to grow to support our portfolio of clients and for this new position, the desired candidate will be a highly qualified, experienced in DMPK and capable of leading a team.

Job Profile

  • Represent DMPK as an integral member of project/core teams, providing scientific excellence and strategic leadership for all stages of drug discovery and early development;
  • Support business development with scientific proposal to help establish and grow the business;
  • Oversee the DMPK team to build internal DMPK assay capabilities to support drug discovery programs;
  • Support DMPK team to design and execute in vitro studies aimed at characterizing the DMPK/ADME properties of small molecule drug candidates;
  • Participate in conducting ADME assays along side the team and have a key role in recruitment and retention of key talent within the department;
  • Communicate DMPK data and provide interpretation of results to project teams, senior management, and other stakeholders;
  • Oversee the preparation of nonclinical DMPK/ADME reports and the relevant sections of documents for regulatory submissions (when appliable);
  • Provide input into the pharmacokinetic and design aspects of nonclinical pharmacology and nonclinical toxicology studies (when appliable);
  • Be a scientific leader and mentor.


  • A MSc or Ph.D. in Biological Science, Chemistry, Pharmacokinetics, Pharmacology or related discipline with 10+ years Industrial experience in Drug Discovery & Development.
  • Verifiable track record of drug discovery experience, success, and leadership, with experience in advancing programs through all stages of discovery to IND candidates.
  • Knowledge of various in vitro & in vivo ADME assays.
  • Ability to work effectively in a dynamic environment with diverse team of coworkers.
  • Solid written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, and attention to detail are necessary.
  • Bilingual (French and English).

Compensation and Benefits


Salary and additional pay

  • Competitive and based on experience;
  • Annual bonus incentive plan.


  • Flexible hours;
  • Health and dental care;
  • Disability and Life insurance;
  • RRSP employer’s matching program;
  • Telemedicine program;
  • Continuing education and Professional development;
  • Casual dress code;
  • Free on-site parking.


  • Monday to Friday